VECTOR ingredient 1 data-ERIOBOTRYA J
ERIOBOTRYA JAPONICA -1000mg/100:1 extract. Eriobotrya Japonica (EJ) or Loquat is a fruiting plant commonly used for food, added to alcholic beverages and sometimes used for health and longevity. EJ contains a host of interesting chemicals with a number of effects that are beneficial to those looking to build muscle, burn fat or increase athletic performance. Loquat for bodybuilders? On the surface EJ doesnt seem to be super exciting but nothing could be further from the truth. There have been a number of studies indicating that the proper extract at a high enough dose can lead to gains in muscle mass, strength and fat loss. Studies indicate EJ Increases the expression of myogenic genes MyoD, Myogenin and MyHC. This increased expression corresponds with an increase in the activity of Creatine Kinase a myogenic differentiation marker. Finally EJ activates the AKT/mTOR pathway and subsequently promotes muscle protein synthesis and a gain in lean muscle mass. In studies EJ was shown to prevent muscle atrophy and increase muscle hypertrophy so its great if your cutting and want to preserve muscle and its great if you want to bulk.
AKT/Mtor Akt is known as effector of insulin/IGF-1 signalling and it can induce muscle hypertrophy through a pathway involving rapamycin-sensitive mTOR. mTOR regulates PGC-1a expression, which is a key regulator of mitochondria biogenesis, and the expression of PGC-1a has been implicated in the control of skeletal muscle mass. The activation of the Akt/mTOR pathway and its downstream targets, p70S6K and PHAS-1/4E-BP1, is requisitely involved in regulating skeletal muscle fiber size. Acute AKT activation also leads to a decrease in adipose tissue (fat loss) QUOTE" The pathways that are sufficient to induce hypertrophy in skeletal muscle have been the subject of some controversy. We describe here the use of a novel method to produce a transgenic mouse in which a constitutively active form of Akt can be inducibly expressed in adult skeletal muscle and thereby demonstrate that acute activation of Akt is sufficient to induce rapid and significant skeletal muscle hypertrophy in vivo, accompanied by activation of the downstream Akt/p70S6 kinase protein synthesis pathway. Upon induction of Akt in skeletal muscle, there was also a significant decrease in adipose tissue. These findings suggest that pharmacologic approaches directed toward activating Akt will be useful in inducing skeletal muscle hypertrophy and that an increase in lean muscle mass is sufficient to decrease fat storage." MyHC Myosin heavy-chain synthesis rate is correlated with measures of muscle strength, circulating insulin-like growth factor 1 and dehydroepiandrosterone sulfate in men and women and free testosterone levels in men. MyoD both MyoD and myogenin genes are necessary in the regenerative process for the proliferation of satellite cells (myoblasts) and for the development of early regenerating fibers (myotubes). The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, Lower doses or the incorrect extraction process has been shown to be ineffective so the extraction process is very important with EJ. So lets dig into whats inside the plant itself. Just a short list of the chemical constituents of EJ- Epicatechin Ursolic acid Chlorogenic acid Corosolic acid Oleanolic acid Caffeic acid Procyanidin B2 Protocatechuic acid Ferulic acid Tormentic acid Naringenin Ellagic acid EGCG Quercetin This is a pretty impressive list of actives. Lets take a look at what some of these do. Epicatechin. EJ doesnt have as much epicatechin as something like cocoa or green tea but there is still a decent amount. Its estimated that there is about 150mg per 100g in cocoa and there is about 60mg in EJ so a little less than half. None the less there is enough that epicatechin will be active especially with Narinigenin, EGCG and quercetin in the mix as these all increase the absorption of epicatechin. Lets think of epicatechin as sort of a bonus. Ursolic acid. There is a decent dose in here at upwards of 150mg estimated per daily dose of our EJ extract but Ursolic acid is also a major constituent of another of Vectors ingredents giving us approx 300mg + of Ursolic acid per dose. Ursolic acid orally has been show in studies to increase muscle mass, Increase strength, Increase brown fat, Increase glucose utilization and increase exercise capacity. Its been stated that UA is not viable orally but I think I disagree and it seems as though studies also indicate that it is orally active although it has a very poor absorption rate. High doses are required and studies indicate 300+ should be enough orally to produce the desired results. Corosolic acid. Corosolic acid is a GDA generally extracted from Banaba (lagerstroemia speciosa) but a significant amount is present in Eribotrya J. Corosolic acid works orally at relatively low doses and has some interesting effects. Even doses of 10mg are viable to display its impressive effects. Most people have heard of Corosolic acid for its glucose effects as it is a major GDA. Corosolic acid can help to keep glucose down with multiple mechanisms of action. Glut4 translocation, reduced insulin resistance as well as all kinds of enzymatic suppression and or expression. -Corosolic acid has been shown to reduce cholesterol levels and enhance lipid metabolism. -Corosolic acid is also a great fat burner not only through antidiabetic effects but also by retarding absorption of fatty acids. -Corosolic acid is a potent and selective inhibitor of the enzyme (11-beta hydroxysteroid dehydrogenase type 1) that converts inactive cortisone to active cortisol. Therefore, corosolic acid may prevent excessive cortisol production. Overall Corosolic acid is one of Vectors great components. Increased Glucose uptake into muscles, decreased blood sugar, increased insulin sensitivity, increased fat utilization and decreased fat diposition plus decreased cortisol make Corosolic a powerhouse. Oleanolic acid Oleanolic acid (OA) is a constituent of Olea Europea, Viscum Album and Eriobotrya japonica as well as others. Its long been used in Chinese medicine for treatment of liver disorders and other ailments. OA increases glucose utilization, is a solid vasodilator and increases expression of the AKT pathway. Protocatechuic acid Insulin like activity by activating PPAPy. Decreases ROS Antiageing Anti inflammatory Antiseptic analgesic GLUT4 upregulation Antioxidant Protects the testes from damage and stress Cardio protective Caffeic acid Increased exercise capacity Reduced Blood Lactate Increased fat loss Endurance Ferulic acid, 4-hydroxy-3-methoxycinnamic acid, is one of the most ubiquitous phenolic acids, found in the bran of grasses such as wheat, rice, and oats. It belongs to the family of plant hydroxycinnamic acids, which include caffeic acid, sinapic acid, and p-coumaric acid. Recent studies have provided evidence that ferulic acid reduces the risk of disease, including Alzheimer’s disease, cardiovascular disease, diabetes, and colon cancer. Currently, ferulic acid is used to enhance athletic performance, both in humans and racehorses. Supplementation by it has been found to increase muscle strength in weight lifters. In one animal study a single acute administration of Ferulic acid increased swimming time by 170%. Ferulic acid prevented the decrease in catalase, superoxide dismutase and protected against the depletion of GST activity induced by exhaustive exercise. Exercise can be associated with oxidative stress. Thus exercise can act as a powerful source of Reactive Oxygen Species, depending on duration and intensity. During exhaustive exercise, fat is typically used as the primary energy source, thus sparing glycogen stores, which in turn retards fatigue. However, during strenuous exercise substantial production of ROS occurs via beta oxidation during the utilization of fat. In addition, a dramatic increase in oxygen consumption in the body creates an imbalance between ROS and the antioxidant defense system resulting in fatigue. Acute adminstration of Ferulic acid prevents fatigue, increases endurance and protects the body during exhaustive exercise. Chlorogenic acid CA often reffered to as green coffee extract is widely known for its antiobesity effects via PPARa agonism and by preventing proliferation of new fat cells. CA can increase muscular glucose uptake both by stimulating Non insulin dependent AMPK as well as stimulating pAKt. Great for keeping bodyfat off while promoting muscle growth. Tormentic acid Anti diabetic Glut4 AMPK REFS: 1.Loquat leaf extract enhances myogenic differentiation, improves muscle function and attenuates muscle loss in aged rats. https://www.ncbi.nlm.nih.gov/m/pubmed/26178971/ 2.Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats. https://www.ncbi.nlm.nih.gov/m/pubmed/26004741/?i=2&from=/26178971/related 3.Effect of Loquat Leaf Extract on Muscle Strength, Muscle Mass, and Muscle Function in Healthy Adults: A Randomized, Double-Blinded, and Placebo-Controlled Trial https://www.hindawi.com/journals/ecam/2016/4301621/ 4.Ethanol Extract of Eriobotrya japonica Leaves Enhanced Swimming Capacity in Mice http://pubs.sciepub.com/jfnr/5/6/8/index.html 5.Cell Suspension Culture of Eriobotrya japonica Regulates the Diabetic and Hyperlipidemic Signs of High-Fat-Fed Mice https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=13&ved=0ahUKEwjF363a_uvXAhVKqVQKHQnWCw0QFghbMAw&url=http%3A%2F%2Fwww.mdpi.com%2F1420-3049%2F18%2F3%2F2726%2Fpdf&usg=AOvVaw3tsGlnXSZOftlHTKRGxosJ 6.Tormentic Acid, a Major Component of Suspension Cells of Eriobotrya japonica, Suppresses High-Fat Diet-Induced Diabetes and Hyperlipidemia by Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation 7. http://pubs.acs.org/doi/abs/10.1021/jf503334d 8. http://pubs.acs.org/doi/abs/10.1021/jf503334d 9. http://www.mdpi.com/1420-3049/18/3/2726/htm 10. https://www.spandidos-publications.com/10.3892/ijmm.2015.2286 11. https://www.ncbi.nlm.nih.gov/pubmed/15485899 12. http://dev.biologists.org/content/132/12/2685 13. https://www.nature.com/articles/srep31142 14. https://www.ncbi.nlm.nih.gov/pubmed/25564701 15. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039332