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Korean mistletoe (Viscum album coloratum) 1000mg @ 100:1 extract. (KME)is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions. KME has been shown to have anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. Of interest to us as athletes KME has been reported to increase strength, muscle mass and improve overall exercise capacity. Of course we love to hear this but these days we want to know how and why so lets explore how KME works. MUSCLE MASS One of the primary goals of the bodybuilder is muscle mass and we know of many things that lead to increased skeletal muscle. Anabolic androgenic steroids are the first things most people think of and for good reason. Anabolic steroids are wonderfully effective and can help you reach levels of muscularity that are just not possible without them. These gains, however, are not without their costs. Anabolic steroids lead to a host of disease states and health issues along with their status as illegal drugs. This makes them less than ideal for most people. Of course there are designer steroids and prohormones and SARMS but these too have their negatives. There has to be a solution. Its been largely demonstrated that nature is a beast of a pharmaceutical lab. Its hard to deny nature as we see that many of the drugs we use come from plants, including most narcotics, chemo meds, nootropics etc. Why then are there not fantastic anabolic agents in nature? There are. KME has been in use as a health agent for ages. Scientists speculated that KME may be anabolic in vivo and a number of clinical studies were conducted to validate this hypothesis. KME has been proven to not only prevent muscle atrophy but also to promote skeletal muscle hypertrophy. This is important because it means that KME both increases muscle growth and prevents muscle which makes it an ultra strong muscle mass building ingredient. Mice Fed KME for 4 weeks showed increases in muscle mass and grip strength. The research indicated multiple factors leading to this result not least of which is the well known AKT/mTOR pathway. Rats fed KME showed increased whole body weight, larger quadriceps and greatly increased strength. It was therefore determined that KME is anabolic as it directly leads to larger stronger muscles. In addition to greater muscle fiber area and diameter KME fed mice showed incredible increases in endurance and exercise capacity making KME an ideal candidate for use in physique, strength and endurance athletes. ENDURANCE/EXERCISE. KME has been shown to decrease fatigue and increase endurance. Increased mitochondrial oxygen consumption and the increased expression of PPARy lead to increases of up to 212% in forced swim tests. KME reduces plasma ammonia levels, improves fuel utilization and enhances exercise performance. In one study researchers adminstered endurance capacity tests. KME fed animals ran TWICE AS FAR as their high fat diet only counterparts which is frankly amazing 100% increases in endurance is like no other natural anabolic currently available. FAT LOSS A big part of what makes anabolic steroids appealing is the ability to build muscle while losing fat. This is the Holy Grail of bodybuilding. Fat loss while building muscle. In a 15 week experiment KME was fed to animals along with a high fat diet. Around week 9 it became evident that the KME fed animals were gaining less weight with no differences in the amount of food taken in. At the end of the experiment the KME fed animals had 20% less bodyfat than their high fat diet only animals and when tested it was determined that the loss was adipose tissue. KME increases thermogenesis and nearly triples the amount of UCP1 (uncoupling protein 1), a principal thermogenic mitochondrial molecule related to energy dissipating in subcutaneous fat. To demonstrate the inhibitory mechanism of KME on fat cells adipogenic factors were studied. They measured the expression levels of the transcription factors PPAR, C/EBP-a, and SREBP-1c in 3T3-L1 cells treated with KME. The results show that PPAR-, C/EBP-a, and SREBP-1c mRNA levels were decreased by 64%, 60%, and 32%, respectively. Finally they also measured the mRNA expression levels of adipogenic enzymes, such as FAS, ACS, and ACC. These adipogenic enzymes were reduced by 69%, 55%, and 22%. Overall the research indicated that adipogenic factors were decreased by 89% compared to that of untreated cells giving KME an unprecidented level of fat loss power for something that is also incredibly anabolic. EFFECTS ON HORMONES. KME has been shown to have a significant impact on the HPTA. KME leads to increased Leutinizing hormone, increased Testosterone and decreased prolactin. This in turn makes VECTOR great for all purposes. Good alone, stacked, even during PCT. Just a few of KME's MOAs= AKT/mTOR In adult skeletal muscle the akt/mTOR signaling pathway is currently recognized as the major pathway regulating protein synthesis. VECTOR activates this pathway and in turn increases protein synthesis and muscle mass. LH increased leutinizing hormone leads to a significant increase in testosterone levels. Atrogin 1- Atrogin-1 is induced in response to myostatin/TGF-b signalling leading to muscle atrophy. Atrogin-1 and MuRF-1 have been identified as important enzymes in ubiquitin-mediated proteolysis and muscle atrophy, and modulating their expression via physical activity or targeting the upstream cytokines and growth factors that regulate their expression has the potential to prevent or reverse muscle atrophy. A reduction in Atrogin 1 prevents loss of muscle. This then makes VECTOR great at helping you hold onto muscle while dieting as its anabolic, anti catabolic and increases fat burning. SMAD2/3 Both myostatin and TGF-ß are held in an inactive form in the muscle extracellular matrix, and when activated, bind to their receptors and activate Smad2/3. Generally speaking we want to see SMAD 2 and 3 drop while seeing an increase in SMAD 7. This is what we see with KME/VECTOR. REFS: 1.- Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy 2.- Atrogin-1, MuRF-1, and sarcopenia 3.- Korean mistletoe (Viscum album coloratum) extract improves endurance capacity in mice by stimulating mitochondrial activity. 4.- A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial 5. 6. 7. 8. 9.